Trifluralin Toxicity in a Chagas Disease Mouse Model

Mouse as a model for Chagas disease: does mouse represent a good model for Chagas disease?

Cholinergic neuropathology in a mouse model of Alzheimer's disease

Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...

Cholinergic neuropathology in a mouse model of Alzheimer's disease

Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...

A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.

Chagas' disease, the leading cause of heart failure in Latin America, is caused by the kinetoplastid protozoan Trypanosoma cruzi. The sterols of T. cruzi resemble those of fungi, both in composition and in biosynthesis. Azole inhibitors of sterol 14alpha-demethylase (CYP51) successfully treat fungal infections in humans, and efforts to adapt the success of antifungal azoles posaconazole and rav...

A Reservoir Model of Chagas Disease

More than 1 billion people all over the world are infected with neglected tropical diseases, such as Chagas disease in Latin and South America. Like malaria, this disease is passed between infected animals and people by an insect, the reduviid bug. In this paper, an ordinary differential equations model was developed that accounts for the existence of a disease reservoir in mammals, such as dom...